#5: Alyssa Milano
Alyssa Milano has remained a prominent force in entertainment and activism long after her Who’s the Boss? days. She reached new heights of fame as Phoebe Halliwell on Charmed, solidifying her status as a television mainstay while continuing to make guest appearances on various shows.

Beyond acting, she became a powerful voice in social movements, bringing the #MeToo movement into the global spotlight with a single, pivotal tweet that exposed widespread sexual misconduct in Hollywood. Balancing her career with activism, Milano continues to use her platform for change, proving her influence extends far beyond the screen.