#28: Ellen Pompeo and Patrick Dempsey

Although Ellen Pompeo and Patrick Dempsey never embarked on a real-life romance, their Grey’s Anatomy characters, Meredith Grey and Derek Shepherd, etched an unforgettable love story on the screen. It’s hard not to envision their fictional children bearing a striking resemblance to these depictions, at the very least.

By the time he stepped into the world of Grey’s Anatomy in 2005, Patrick Dempsey was happily married in his personal life, drawing a clear line between fiction and reality as he brought the iconic McDreamy to life on screen.